Biosignatures for Parkinson’s Disease and Atypical Parkinsonian Disorders Patients
نویسندگان
چکیده
منابع مشابه
Biosignatures for Parkinson’s Disease and Atypical Parkinsonian Disorders Patients
Diagnosis of Parkinson' disease (PD) carries a high misdiagnosis rate due to failure to recognize atypical parkinsonian disorders (APD). Usually by the time of diagnosis greater than 60% of the neurons in the substantia nigra are dead. Therefore, early detection would be beneficial so that therapeutic intervention may be initiated early in the disease process. We used splice variant-specific mi...
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Atypical parkinsonism encompasses several disorders that may have disease-specific or individualspecific characteristics, however common features include akinesia, rigidity, gait difficulties, and cognitive decline with gradual worsening of the symptoms. These features result in a variety of deficits that affect the patient’s ability to function in their usual capacity at home, on the job, and ...
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Although the clinical syndrome of parkinsonism (rigidity, bradykinesia, and tremor) is most often owing to idiopathic Parkinson’s disease (PD), it may also be associated with a variety of other underlying pathologies (Table 1) (1–3). Each of these other pathological conditions tends to have a characteristic clinical phenotype, however atypical cases are increasingly recognized (4–8). Moreover, ...
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Studying archetypes is a fundamental task in nosography. Duchenne de Boulogne practiced it instinctively, and many others have done it before and after him: It is indispensable, and the only way to extract a specific pathological state from the chaos of imprecision. The history of medicine, which is long and grand, shows this truth well. But once the archetype is established, the second nosogra...
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Parkinson’s disease (PD) is defined clinically as a disorder characterized by the presence of at least two of four cardinal signs, i.e., resting tremor, bradykinesia, rigidity, and postural instability, along with a good response to levodopa (1). Patients with typical PD do not manifest ataxia, chorea, orthostatic hypotension unrelated to medications, vertical downward-gaze deficits, amyotrophy...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0043595